Mani N
J Clin Chem Clin Biochem. 1981 Jun;19(6):311-22.
The discipline of chemical pathology, earlier known as pathological chemistry, arose from the attempt to apply chemistry to medicine. Two main origins of the subject can be identified: the development of scientific research in medicine, and the emergence of organic chemistry and physiological chemistry. The development of clinical chemistry and its two historical roots in the 19th century are traced from their beginnings, together with the contributions from biology and natural philosophy. A vitalistic view of chemistry in the biosciences, the identification of natural products and the study of their metabolism all favoured the early establishment of clinical chemistry at the end of the first half of the 19th century. This was followed by a rise of fundamental research in physiological chemistry, while clinical laboratories remained as application-orientated adjuncts of clinical medicine, with the task of diagnosis.
化学病理学学科，早期称为病理化学，源自将化学应用于医学的尝试。该学科有两个主要起源：医学科研的发展以及有机化学和生理化学的出现。临床化学的发展及其在19世纪的两个历史根源从其起源开始追溯，同时还有生物学和自然哲学的贡献。生物科学中对化学的生机论观点、天然产物的鉴定及其代谢研究都有利于临床化学在19世纪上半叶末的早期建立。随后是生理化学基础研究的兴起，而临床实验室仍然是临床医学以应用为导向的附属机构，承担诊断任务。
