50例年轻心肌梗死患者血小板对抗聚集性前列腺素（前列环素、前列腺素E1、前列腺素D2）的敏感性价值。
Value of platelet sensitivity to antiaggregatory prostaglandins (PGI2, PGE1, PGD2) in 50 patients with myocardial infarction at young age.
作者信息
Sinzinger H, Kaliman J, Widhalm K, Pachinger O, Probst P
出版信息
Prostaglandins Med. 1981 Aug;7(2):125-32. doi: 10.1016/0161-4630(81)90056-2.
Based upon earlier findings of our group that not only the synthesis of antiaggregatory prostaglandins by the vessel wall is altered in atherosclerotic vascular tissue of patients, but also the sensitivity of their platelets to these prostaglandins is changed, we examined a well defined group of 50 patients with myocardial infarction before the age of 40 years. In all patients the coronary heart disease was verified by angiography. The sensitivity of the platelets was examined in relation ot the smoking habit, the type and presence of hyperlipoproteinemia, one, two and three vessel disease and familial history. Except for hyperlipoproteinemia and smoking, all the patients were free of any additional risk factor. It is demonstrated that the platelet sensitivity to the antiaggregatory prostaglandins is significantly diminished in hyperlipoproteinemics in comparison to a control group.
基于我们小组早期的研究发现，即不仅患者动脉粥样硬化血管组织中血管壁抗聚集前列腺素的合成发生改变，而且其血小板对这些前列腺素的敏感性也发生变化，我们对一组明确的50例40岁以下心肌梗死患者进行了检查。所有患者的冠心病均经血管造影证实。根据吸烟习惯、高脂蛋白血症的类型和存在情况、单支、双支和三支血管病变以及家族史对血小板敏感性进行了检查。除高脂蛋白血症和吸烟外，所有患者均无任何其他危险因素。结果表明，与对照组相比，高脂蛋白血症患者血小板对抗聚集前列腺素的敏感性显著降低。
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