Ylikorkala O, Viinikka L
Prostaglandins Med. 1981 Aug;7(2):95-9. doi: 10.1016/0161-4630(81)90053-7.
To study the production of antiaggregatory and vasodilatory prostacyclin (PGI2) during human pregnancy and puerperium, we measured the concentrations of 6-keto-prostaglandin F1alpha, the stable hydration product of PGI2, with specific radio-immunoassay in plasma samples from 53 women between 11 and 41 weeks of normal pregnancy, 11 puerperal women 53-60 days postpartum and 20 healthy nonpregnant control women. The levels of 6-keto-PGF1alpha did not change during the course of pregnancy, and the mean (+/- SE) levels of 6-keto-PGF1alpha during pregnancy (255.5 +/- 8.7 pg/ml) or puerperium (254.7 +/- 12.3 pg/ml) were not significantly different from the mean level of 277.7 +/- 10.6 pg/ml in the nonpregnant control women. There was no correlation between the 6-keto-PGF1alpha concentration and pregnancy week, maternal age, parity or lactation. Thus, it is evident that PGI2, as measured by its metabolite levels in maternal plasma, does not change during human gestation.
为研究人类妊娠和产褥期抗聚集和血管舒张性前列环素（PGI2）的产生情况，我们采用特异性放射免疫分析法，测定了53例妊娠11至41周的正常孕妇、11例产后53至60天的产褥期妇女以及20例健康非孕对照妇女血浆样本中PGI2的稳定水解产物6-酮-前列腺素F1α的浓度。6-酮-前列腺素F1α的水平在妊娠过程中未发生变化，妊娠期间（255.5±8.7 pg/ml）或产褥期（254.7±12.3 pg/ml）的6-酮-前列腺素F1α平均水平与非孕对照妇女的平均水平277.7±10.6 pg/ml无显著差异。6-酮-前列腺素F1α浓度与孕周、产妇年龄、产次或哺乳情况均无相关性。因此，显而易见，通过母体血浆中其代谢产物水平测定的PGI2在人类妊娠期不会发生变化。
