Ylikorkala O, Mäkäräinen L, Viinikka L
Br J Obstet Gynaecol. 1981 May;88(5):513-6. doi: 10.1111/j.1471-0528.1981.tb01025.x.
The role of prostacyclin (PGI2) in human parturition was studied by measuring the concentrations of its main metabolite, 6-keto-prostaglandin F1 alpha, before, during and after term labour in the plasma of 9 women and after delivery in umbilical artery and vein plasma. The mean level of 6-keto-PGF1 alpha rose significantly over the course of labour. The mean level was 266 pg/ml before labour, 341 pg/ml in the presence of regular contraction, 387 pg/ml at a cervical dilatation of 5 cm, 386 pg/ml at delivery, and 397 pg/ml at the expulsion of the placenta. The 6-keto-PGF1 alpha concentration dropped to below pre-labour levels of 233 pg/ml within 2 hours of delivery, and this level was maintained for the first four postpartum days. The mean levels of 6-keto-PGF1 alpha in the umbilical artery and vein plasma, 1667 and 1193 pg/ml respectively, were significantly higher than the maternal plasma levels. PGI2 is characterized by its antiaggregatory and vasodilating abilities, so that the rise in PGI2 during labour may play a role in the prevention of intrapartum thromboembolic complications in the maternal and the uteroplacental circulation.
通过检测9名女性足月分娩前、分娩期间及分娩后血浆中前列环素（PGI2）主要代谢产物6-酮-前列腺素F1α的浓度，以及分娩后脐动脉和脐静脉血浆中的浓度，研究了PGI2在人类分娩中的作用。在分娩过程中，6-酮-前列腺素F1α的平均水平显著升高。分娩前平均水平为266 pg/ml，规律宫缩时为341 pg/ml，宫颈扩张5 cm时为387 pg/ml，分娩时为386 pg/ml，胎盘娩出时为397 pg/ml。分娩后2小时内，6-酮-前列腺素F1α浓度降至分娩前水平以下，为233 pg/ml，且在产后头四天维持该水平。脐动脉和脐静脉血浆中6-酮-前列腺素F1α的平均水平分别为1667 pg/ml和1193 pg/ml，显著高于母体血浆水平。PGI2具有抗聚集和血管舒张能力，因此分娩期间PGI2的升高可能在预防母体和子宫胎盘循环中的产时血栓栓塞并发症方面发挥作用。
