Van Hoof F, Verheyden J
Sci Total Environ. 1981 Aug;20(1):15-22. doi: 10.1016/0048-9697(81)90033-4.
Frameshift mutagens have been detected in the river Meuse downstream of Liège In most cases, mutagenic activity could only be demonstrated afte metabolic activation. The effect was inversely related to river flow. The most important sewage outfalls and industrial discharges in the area were controlled on mutagenic activity. Two effluents, both discharging cokes-oven effluents, were found to contain high quantities of frameshift mutagens. The effluents were split up in neutral, acidic and basic fractions. Only neutral and basic fractions showed mutagenic activity. They were further separated in subfractions by gel chromatography and adsorption chromatography. The mutagenic activity was shown to be present in subfractions containing polynuclear aromatic hydrocarbons and aza-arenes. Mutagenic activity in river water samples could only be located in the polynuclear aromatic hydrocarbon fractions.
在列日下游的默兹河中检测到了移码诱变剂。在大多数情况下，诱变活性只有在代谢激活后才能得到证实。这种效应与河流流量呈负相关。该地区最重要的污水排放口和工业排放物都受到了诱变活性的控制。发现两种都排放焦炉废水的污水含有大量移码诱变剂。这些污水被分离成中性、酸性和碱性馏分。只有中性和碱性馏分显示出诱变活性。它们通过凝胶色谱法和吸附色谱法进一步分离成亚馏分。诱变活性显示存在于含有多环芳烃和氮杂芳烃的亚馏分中。河水样本中的诱变活性仅存在于多环芳烃馏分中。
