Grieben A
S Afr Med J. 1981 Sep 5;60(10):395-7.
In vitro and in vivo experimental work showed that gentamicin-polymethyl-methacrylate (G-PMMA) provides bactericidal gentamicin concentrations at the site of infection but very low systemic concentrations, suggesting advantages as regards infection control and lack of side-effects. During the past 4 years 1247 osteomyelitis patients have been treated with G-PMMA at 11 clinics. The early postoperative results showed control of infection in 90.8% of cases. Infection persisted in 9.2% owing to remaining sequestra, osteosynthetic material, etc. This indicates the importance of good and radical surgery. Follow-up of 355 patients for 3 - 54 months postoperatively showed relapses in only 27 cases. A total of 361 patients with soft-tissue infections (e.g. associated with bone infections, sacral cavity after rectum excision, abscesses, etc.) underwent treatment with G-PMMA after thorough debridement, with good results. Techniques for implantation, and removal of the chains are discussed. No adverse effects have been observed in this series of trials.
体外和体内实验研究表明，庆大霉素-聚甲基丙烯酸甲酯（G-PMMA）在感染部位可提供杀菌浓度的庆大霉素，但全身浓度极低，这表明其在控制感染方面具有优势且无副作用。在过去4年中，11家诊所的1247例骨髓炎患者接受了G-PMMA治疗。术后早期结果显示，90.8%的病例感染得到控制。由于存在残留死骨、骨合成材料等，9.2%的患者感染持续存在。这表明了良好且彻底手术的重要性。对355例患者进行术后3至54个月的随访，仅27例出现复发。共有361例软组织感染患者（如与骨感染相关、直肠切除术后骶腔感染、脓肿等）在彻底清创后接受了G-PMMA治疗，效果良好。文中讨论了植入及取出链的技术。在这一系列试验中未观察到不良反应。
