Ratovitskiĭ E A, Pliusnin A Z
Tsitologiia. 1981 Jul;23(7):723-44.
The modern views on the organization and expression of single genes in eukaryotic cells, RNA structure and biosynthesis are reviewed. The problems of unstable gene localization ("mobile dispersed genetic elements") of some structural genes of cellular and viral origin are discussed. Peculiarities of transcription and processing of mRNA, pre-mRNA splicing are described. The information on the mechanisms of pre-mRNA splicing in normal and virus-infected eukaryotic cells, the role of low molecular nuclear RNA in the RNA splicing as signals for less than recognition greater than by specific nucleases and RNA synthetases are also regarded.
本文综述了关于真核细胞中单个基因的组织与表达、RNA结构及生物合成的现代观点。讨论了细胞和病毒来源的一些结构基因的不稳定基因定位(“移动分散遗传元件”)问题。描述了mRNA转录和加工、前体mRNA剪接的特点。还探讨了正常和病毒感染的真核细胞中前体mRNA剪接机制的相关信息,以及低分子核RNA在RNA剪接中作为特定核酸酶和RNA合成酶识别信号的作用。