Schultz K, Mestyán J, Soltész G, Klujber L, Dóber I
Acta Paediatr Acad Sci Hung. 1980;21(4):243-51.
Blood samples were obtained from 13 infants with clinically and microbiologically confirmed septicaemia. Two subgroups of the septic infants were formed according to postnatal age, an early onset group consisting of 6 infants younger than 7 days, and a late onset group comprising 7 infants of 20 infants. The blood samples were analysed for 18 plasma amino acids and glucose, lactate and FFA. Except the significantly lowered blood glucose in the early onset group of infants, no appreciable change occurred in the glucose, lactate and FFA levels. The plasma aminogram was different in the two groups, as hypoaminoacidaemia was more pronounced in the early onset group. The branched chain amino acids decreased significantly in both groups. The three important glucogenic amino acids alanine, glycine and proline showed a decrease only in the early onset group. Among the calculated plasma amino acid ratios the phenylalanine: tyrosine quotient was markedly increased. This, in addition to the response of the branched chain amino acids, has been found characteristic of a variety of clinical and experimental infections.
从13例临床和微生物学确诊败血症的婴儿中采集血样。根据出生后年龄将败血症婴儿分为两个亚组，早发组由6名小于7天的婴儿组成，晚发组由7名20名婴儿中的7名组成。对血样进行18种血浆氨基酸以及葡萄糖、乳酸和游离脂肪酸分析。除早发组婴儿血糖显著降低外，葡萄糖、乳酸和游离脂肪酸水平无明显变化。两组血浆氨基酸谱不同，早发组低氨基酸血症更明显。两组支链氨基酸均显著降低。三种重要的生糖氨基酸丙氨酸、甘氨酸和脯氨酸仅在早发组中降低。在计算的血浆氨基酸比值中，苯丙氨酸：酪氨酸商显著升高。除支链氨基酸的反应外，这已被发现是各种临床和实验性感染的特征。
