[Dynamics of tissue reactions following allotransplantation of a complete thickness skin flap in mice. 1. Epidermis and its derivatives].

A complete skin graft (1.5 x 2.5 cm) from mice C3H was transplanted to mice C57Bl. Destructive changes in epidermis and its cells were accompanied by its infiltration with lymphocytes and polymorphonuclear leucocytes. After these phenomena intensified, signs of epithelial regeneration appeared at the expense of cambial elements in the area of hairy follicles an sebaceous glands. In response to the epithelial regeneration, lymphocytic infiltration increased, that was followed by destruction of a greater part (but not all) cells of the regenerate. Then another, though a weak, wave of regeneration occurred with a corresponding increase in number of viable epithelial cells was noted on the 66th, 164th and 226th h, and increase -- on the 94--104th and 194th h after the operation. That demonstrated certain rhythmicity in the rejection with the period of about 4 days.