[Changes in the cell population of the thymus-dependent area of the regional lymph nodes following skin flap grafting].

In the paracortical zone of the regional lymph node changes in the cell population density of small and middle lymphocytes, immunoblasts, immature and mature plasma cells are taken into consideration. The observations are carried out for 954 h after transplantation. As demonstrates the analysis of the process segmentation, certain stages of the changes are revealed with duration of 150-160 h; that corresponds to circadian (circaseptan) range of biological rhythms. The duration of the first stage makes about a half of the circaseptan period. In quantitative changes of every cell type a slow trend and a periodical component are present. It is possible to suppose that during the first 3-4 days mobilization of cell resources takes place, further up to 13-16 days active reactions occur, directed to exfoliation of allogenic tissue components, and then after the exfoliation of the graft the amount of the cells becomes stable, however, rhythmical fluctuations are preserved. The reaction of the cell composition in the paracortical zone of the lymph nodes is in concord with the dynamics of changes in the cell population and in the transplant itself.