Koch P S, Jakobiec F A, Iwamoto T, Troutman R C, Swinger C A
Arch Ophthalmol. 1981 Sep;99(9):1634-9. doi: 10.1001/archopht.1981.03930020508023.
Three patients experienced technical failures from their keratophakia procedures and their lenticles were removed at intervals of three days, 2 1/2 months, and nine months, respectively, postoperatively. All three lenticles displayed, by both light and electron microscopy, degeneration of their keratocytes without any evidence of repopulation by the host's keratocytes. Small increases in amorphous material were noted between the collagen fibrils, but the stromal lamellae were otherwise well preserved and oriented. There was not clear evidence of new collagen production at the edges of the lenticles. One failure was caused by the mistaken inclusion of Descemet's membrane in the lenticle. Another specimen with epithelial ingrowth also displayed degeneration of the collagen fibrils along one edge; this degeneration was possibly the result of collagenase activity.
三名患者在角膜磨镶术过程中出现技术故障，术后分别在3天、2个半月和9个月时取出了晶状体。通过光学显微镜和电子显微镜观察，所有三个晶状体的角膜细胞均发生退化，没有任何宿主角膜细胞重新填充的迹象。在胶原纤维之间观察到无定形物质略有增加，但基质板层在其他方面保存完好且排列有序。在晶状体边缘没有明确的新胶原产生的证据。一次失败是由于在晶状体中错误地包含了Descemet膜。另一个伴有上皮内生的标本在一条边缘处也显示出胶原纤维的退化；这种退化可能是胶原酶活性的结果。
