MacKenzie I Z, Fry A
Br J Obstet Gynaecol. 1981 Oct;88(10):1033-7. doi: 10.1111/j.1471-0528.1981.tb01693.x.
Using a double blind administration protocol, the effect on the cervix of prostaglandin E2 (PGE2) vaginal pessaries inserted one to six hours before aspiration termination of pregnancy has been assessed. Pessaries containing 10 mg of PGE2 produced significant cervical softening and dilatation compared with those containing only 5 mg of PGE2 or placebo, the effect was almost as good as 15 mg of PGE2 but the lower dose caused fewer gastro-intestinal side-effects and uterine cramps. Blood loss at abortion and in the early post-abortal recovery period was significantly reduced following PGE2 treatment compared with placebo. The method described is simple and effective in reducing difficult cervical dilatation and is appropriate for day-care abortion management.
采用双盲给药方案，评估了在妊娠终止吸宫术前1至6小时插入前列腺素E2（PGE2）阴道栓剂对宫颈的影响。与仅含5毫克PGE2或安慰剂的栓剂相比，含10毫克PGE2的栓剂可使宫颈显著软化和扩张，其效果与15毫克PGE2几乎相同，但较低剂量引起的胃肠道副作用和子宫痉挛较少。与安慰剂相比，PGE2治疗后流产时及流产后早期恢复期的失血量显著减少。所描述的方法在减少宫颈扩张困难方面简单有效，适用于日间流产管理。
