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A new prostaglandin E2-gel for pretreatment of the cervix in nulliparous patients having a late first trimester termination of pregnancy.

作者信息

Wingerup L, Ulmsten U, Bygdeman M, Ekman G, Hamberger L, Lundström V, Norström A

出版信息

Arch Gynecol. 1981;231(1):1-6. doi: 10.1007/BF02110018.

DOI:10.1007/BF02110018
PMID:6949498
Abstract

A new PGE2-gel, based on a cross-linked starch powder, has been developed. This gel seems to have solved several of the pharmaceutical and practical problems connected with local administration of prostaglandins. In a three-center study 120 nulliparous patients were given 0.5 mg PGE2 in 2.2 ml gel intracervically prior to dilatation of the cervix and evacuation of the uterus in late first trimester. Considerable cervical dilatation was obtained within 15 h. The frequency of side effects, including pain and gastro-intestinal discomfort was low. The technique can be recommended for outpatients.

摘要

相似文献

1
A new prostaglandin E2-gel for pretreatment of the cervix in nulliparous patients having a late first trimester termination of pregnancy.
Arch Gynecol. 1981;231(1):1-6. doi: 10.1007/BF02110018.
2
Comparative study of various intracervically administered PG gel preparations for termination of first trimester pregnancies.不同宫颈内给药的前列腺素凝胶制剂用于终止早期妊娠的比较研究。
Contraception. 1983 Sep;28(3):209-22. doi: 10.1016/0010-7824(83)90062-8.
3
Cervical dilatation with prostaglandin analogues prior to vaginal termination of first trimester pregnancy in nulliparous patients.未产妇在孕早期经阴道终止妊娠前使用前列腺素类似物进行宫颈扩张。
Prostaglandins. 1975 Apr;9(4):631-8. doi: 10.1016/0090-6980(75)90069-6.
4
Efficacy of an intracervical prostaglandin E2 preparation, Cerviprost, on cervical ripening before first trimester abortion in nulliparous patients.一种宫颈内前列腺素E2制剂（Cerviprost）对未生育患者孕早期流产前宫颈成熟的疗效。
J Obstet Gynaecol (Lahore). 1989;10(2):120-3. doi: 10.3109/01443618909151126.
5
Preoperative administration of prostaglandin to avoid dilatation-induced damage in first-trimester pregnancy terminations.
Gynecol Obstet Invest. 1981;12(1):29-36. doi: 10.1159/000299565.
6
Dilatation of the cervix by oral PGE2 before first-trimester termination of pregnancy.孕早期终止妊娠前经口服前列腺素E2扩张宫颈。
Acta Obstet Gynecol Scand. 1984;63(7):625-8. doi: 10.3109/00016348409155550.
7
A comparison of two stable prostaglandin E analogues for termination of early pregnancy and for cervical dilatation.两种稳定前列腺素E类似物用于早期妊娠终止和宫颈扩张的比较。
Contraception. 1980 Nov;22(5):471-83. doi: 10.1016/0010-7824(80)90100-6.
8
Effects of intracervical PGE2-gel on myometrial activity and cervical state in first trimester pregnancy.宫颈内给予前列腺素E2凝胶对孕早期子宫肌层活动及宫颈状态的影响。
Prostaglandins. 1982 Sep;24(3):303-12. doi: 10.1016/0090-6980(82)90157-5.
9
Intramuscular administration of 16 phenoxy omega 17,18,19,20 tetranor PGE2 methyl sulfonylamide for pre-operative cervical dilatation in first trimester nulliparae.对孕早期初产妇进行术前宫颈扩张时，肌肉注射16-苯氧基-ω-17,18,19,20-四降前列地尔甲磺酰胺。
Prostaglandins Med. 1978 Jul;1(1):71-5. doi: 10.1016/0161-4630(78)90078-2.
10
Cervical priming before first trimester aspiration abortion: a single blind study comparing gemeprost 1 mg and prostaglandin E2 10 mg pessaries.孕早期负压吸宫术前的宫颈准备：一项比较1毫克吉美前列素与10毫克前列腺素E2阴道栓剂的单盲研究。
J Obstet Gynaecol (Lahore). 1990 Oct;10(6):513-7. doi: 10.3109/01443619009151257.

引用本文的文献

1
Intracervical instillation of PGE2-gel in patients with missed abortion or intrauterine fetal death.对稽留流产或死胎患者进行宫颈内前列腺素E2凝胶灌注。
Arch Gynecol. 1983;233(4):241-5. doi: 10.1007/BF02133797.

本文引用的文献

1
A comparison of two stable prostaglandin E analogues for termination of early pregnancy and for cervical dilatation.两种稳定前列腺素E类似物用于早期妊娠终止和宫颈扩张的比较。
Contraception. 1980 Nov;22(5):471-83. doi: 10.1016/0010-7824(80)90100-6.
2
Preparation, characterization, and stability of new prostaglandin E2 gel for local administration.用于局部给药的新型前列腺素E2凝胶的制备、表征及稳定性
J Pharm Sci. 1980 Nov;69(11):1271-3. doi: 10.1002/jps.2600691110.
3
Vaginal administration of 15-methyl-PGF2 alpha methyl ester for preoperative cervical dilatation. Task force on prostaglandins for fertility regulation. The World Health Organization.
Contraception. 1981 Mar;23(3):251-9.
4
Clinical experiences with a new gel for intracervical application of prostaglandin E2 before therapeutic abortion or induction of term labor.一种用于治疗性流产或足月引产术前宫颈内应用前列腺素E2的新型凝胶的临床经验。
Prostaglandins. 1980 Sep;20(3):533-46. doi: 10.1016/0090-6980(80)90041-6.
5
Vaginally administered PGF2alpha for cervical dilatation in nulliparas prior to suction curettage.在进行负压刮宫术前，经阴道给予未产妇前列腺素F2α以扩张宫颈。
Prostaglandins. 1973 Dec;4(6):819-36. doi: 10.1016/0090-6980(73)90117-2.
6
Administration of 15-methyl-prostaglandin F2alpha as a pre-operative means of cervical dilatation.给予15-甲基前列腺素F2α作为术前宫颈扩张的一种方法。
Prostaglandins. 1973 Sep;4(3):371-9. doi: 10.1016/0090-6980(73)90024-5.
7
Sonar measurement of fetal crown-rump length as means of assessing maturity in first trimester of pregnancy.超声测量胎儿头臀长作为评估妊娠早期成熟度的方法。
Br Med J. 1973 Oct 6;4(5883):28-31. doi: 10.1136/bmj.4.5883.28.
8
Induction of abortion by the extra-amniotic administration of prostaglandin gels.经羊膜外给予前列腺素凝胶引产。
J Obstet Gynaecol Br Commonw. 1973 Nov;80(11):1025-7. doi: 10.1111/j.1471-0528.1973.tb02970.x.
9
Ripening of the cervix with extra-amniotic prostaglandin E2 in viscous gel before induction of labour.在引产之前，使用粘性凝胶中的羊膜外前列腺素E2使宫颈成熟。
Br J Obstet Gynaecol. 1977 Apr;84(4):264-8. doi: 10.1111/j.1471-0528.1977.tb12574.x.
10
Changes in cervical compliance at parturition independent of uterine activity.分娩时宫颈顺应性的变化与子宫活动无关。
Am J Obstet Gynecol. 1978 Feb 15;130(4):414-8. doi: 10.1016/0002-9378(78)90282-x.