大鼠体内胰岛素的肠内给药。
Enteral administration of insulin in the rat.
作者信息
Bar-On H, Berry E M, Eldor A, Kidron M, Lichtenberg D, Ziv E
出版信息
Br J Pharmacol. 1981 May;73(1):21-4. doi: 10.1111/j.1476-5381.1981.tb16766.x.
Abstract
1 The effect of the surfactant, Cetomacrogol 1000, on the absorption of insulin across the rectal mucosa has been studied. 2 Rectal administration of microenemata containing Cetomacrogal 1000 and insulin causes a rise in the plasma concentration of insulin and a consequent fall in the blood glucose concentration in diabetic and non-diabetic rats. 3 The hypoglycaemic response is dependent on both the concentration of surfactant and the dose of insulin administered. 4 The results suggest that the transport of insulin across the rectal mucosa is facilitated by Cetomacrogal 1000.
摘要
研究了表面活性剂鲸蜡醇聚醚1000对胰岛素经直肠黏膜吸收的影响。
给糖尿病和非糖尿病大鼠直肠给予含鲸蜡醇聚醚1000和胰岛素的微灌肠剂后，血浆胰岛素浓度升高，血糖浓度随之下降。
降血糖反应取决于表面活性剂的浓度和所给予的胰岛素剂量。
结果表明，鲸蜡醇聚醚1000促进胰岛素经直肠黏膜的转运。
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本文引用的文献
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Lancet. 1973 Apr 14;1(7807):794-7. doi: 10.1016/s0140-6736(73)90599-0.
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The gastrointestinal absorption of liposomally entrapped insulin in normal rats [proceedings].正常大鼠中脂质体包裹胰岛素的胃肠道吸收[会议论文集]
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