Doig P A, McKnight J D, Miller R B
Can Vet J. 1981 Mar;22(3):72-6.
The results of a study on endometrial biopsies obtained from 700 infertile mares are reported. Infiltrative endometritis was present in 51% consisting of a combination of an acute and chronic cellular response in 6%, mild chronic infiltrations in 35% and moderate to severe chronic infiltrations in 10%. Demonstrable endometrial fibrosis was found in 88% of the mares with the majority having mild (51%) or moderate (35%) changes. The age of the mares and the average number of years barren gradually increased with the severity of endometrial fibrosis, as did the combined incidence of fetal loss (early embryonic death and abortion) during the three year period preceding the biopsy.A significant decrease in foaling percentage for the year following the biopsy was observed with increasing severity of endometrial fibrosis. Chisquare analysis projected a decrease in foaling rate of 22.8% for each category increase in severity. The number of years barren and the farm management system used also had a significant effect on foaling probability. The foaling rates for mares that were bred artificially (82%) under strict veterinary supervision using an extender incorporating gentamicin were significantly (P < 0.05) higher than for mares bred in a conventional manner under average management conditions (48%). It was concluded that endometrial biopsy is a valuable diagnostic and prognostic technique. When the degree of fibrosis is used to predict foaling probability, the number of years barren and the breeding method to be used should also be considered to arrive at a more accurate prediction.
本文报告了一项对700匹不育母马子宫内膜活检结果的研究。51%的母马存在浸润性子宫内膜炎，其中6%表现为急性和慢性细胞反应的组合，35%为轻度慢性浸润，10%为中度至重度慢性浸润。88%的母马存在明显的子宫内膜纤维化，大多数为轻度（51%）或中度（35%）变化。母马的年龄和平均不育年限随着子宫内膜纤维化的严重程度逐渐增加，活检前三年期间胎儿丢失（早期胚胎死亡和流产）的合并发生率也随之增加。随着子宫内膜纤维化严重程度的增加，活检后一年的产驹率显著下降。卡方分析表明，严重程度每增加一个等级，产驹率下降22.8%。不育年限和所采用的农场管理系统对产驹概率也有显著影响。在严格兽医监督下使用含庆大霉素的稀释液进行人工授精的母马（82%）的产驹率显著高于（P<0.05）在一般管理条件下采用传统方式配种的母马（48%）。研究得出结论，子宫内膜活检是一种有价值的诊断和预后技术。当用纤维化程度预测产驹概率时，还应考虑不育年限和所采用的配种方法，以获得更准确的预测。
