Salih S Y, Abu Sabaa H, Mustafa D
J Trop Med Hyg. 1978 Jul;81(7):126-30.
The results of a clinical trial of hycanthone in 601 selected Sudanese patients with S. mansoni and S. haematobium infections are reported. Hycanthone was given as a single intramuscular injection at a dose of 3.0 mg per kilogramme body weight. The commonest side effects were nausea and vomiting which occurred in 35 per cent and 32 per cent respectively. No incidence of acute hepatic damage and no deaths were encountered. About one third of patients reported for follow-up. Cure rate for S. mansoni was 90 per cent at 6 weeks of treatment and 97 per cent at three months and six months, while for S. haematobium infection it was 82 per cent at 6 weeks and 91 per cent at 3 months and 6 months. A significant reduction in egg excretion was achieved in those who were not cured.
报告了对601名选定的患有曼氏血吸虫和埃及血吸虫感染的苏丹患者进行的海恩酮临床试验结果。海恩酮以每公斤体重3.0毫克的剂量进行单次肌肉注射。最常见的副作用分别是恶心和呕吐，发生率分别为35%和32%。未发现急性肝损伤病例，也无死亡情况。约三分之一的患者前来接受随访。曼氏血吸虫病的治愈率在治疗6周时为90%，在3个月和6个月时为97%，而埃及血吸虫感染在6周时为82%，在3个月和6个月时为91%。未治愈患者的虫卵排泄量显著减少。
