Kniazev Iu A, Vakhrusheva L L, Stupin I V
Probl Endokrinol (Mosk). 1981 Jul-Aug;27(4):39-41.
Insulin, C-peptide and glucose levels in the blood, collected from the portal, hepatic and femoral veins of 7 young healthy dogs were studied before and 3 to 45 minutes after intravenous glucose injection. It was found that insulin concentration in the peripheral vein does not reflect completely its secretion by pancreatic islets, since a considerable part of hormone, released after glucose injection, is retained by the liver. C-peptide concentration in the peripheral veins reflects more precisely the beta-cell secretory activity that insulin level. A rise of insulin concentration in the portal vein after intravenous glucose injection promotes the hepatic glucose assimilation.
对7只年轻健康犬的门静脉、肝静脉和股静脉采血，研究静脉注射葡萄糖前后血液中胰岛素、C肽和葡萄糖水平。研究发现，外周静脉中的胰岛素浓度并不能完全反映胰岛的分泌情况，因为葡萄糖注射后释放的相当一部分激素被肝脏截留。外周静脉中的C肽浓度比胰岛素水平更能准确反映β细胞的分泌活性。静脉注射葡萄糖后门静脉中胰岛素浓度的升高促进了肝脏对葡萄糖的同化作用。
