Gorchakov V D, Petrunin D D, Riabova V L, Evseev N G, Gofman Ia B
Vopr Med Khim. 1981;27(4):544-7.
Sorption of specific immunoglobulins in the most obvious mechanism of the detoxicating effect of haemosorption in autoimmune diseases. Biochemical analyses of blood from patients with psoriasis showed that content of immunoglobulins was not distinctly altered before and after haemosorption. Determination of the protein spectrum to find the absorbed components was carried out by means of immunization of rabbits with the carbon suspension, obtained from the patients with psoriasis after haemosorption. Immunoglobulin G constituted the main amount of the absorbed protein. Sorption of albumin was studied in model experiments in order to determine the optimal pore structure of carbon haemosorbents. Capacity of active carbons to the protein sorption depended only on volume of transient pores. These data enabled to work out the recommendations for synthesis of active carbons with improved efficiency to sorption of protein components from blood plasma.
特异性免疫球蛋白的吸附是血液吸附在自身免疫性疾病中解毒作用最明显的机制。对银屑病患者血液的生化分析表明，血液吸附前后免疫球蛋白的含量没有明显改变。通过用血液吸附后银屑病患者的碳悬浮液免疫兔子来测定蛋白质谱，以找出被吸附的成分。免疫球蛋白G构成了被吸附蛋白质的主要部分。为了确定碳血液吸附剂的最佳孔结构，在模型实验中研究了白蛋白的吸附情况。活性炭对蛋白质的吸附能力仅取决于过渡孔的体积。这些数据有助于制定关于合成对血浆中蛋白质成分吸附效率更高的活性炭的建议。
