Yasujima M, Abe K, Chiba S, Sato M, Irokawa N, Seino M, Imai Y, Saito K, Sakurai Y, Ito T, Haruyama T, Ritsu K, Yoshinaga K
Jpn Circ J. 1978 May;42(5):565-9. doi: 10.1253/jcj.42.565.
To investigate the role of renal prostaglandin in the regulation of sodium metabolism, ruinary prostaglandin E excretion, an indicator of renal prostaglandin synthesis, urinary sodium excretion, plasma renin activity and urinary aldosterone excretion were measured in 84 normal subjects and 55 patients with essential hypertension on ad lib intake of sodium. The excretion rates of urinary prostaglandin E were 736.8 +/- 32.2 ng/day in normal subjects and 394.3 +/- 28.7 ng/day in essential hypertensives. The excretion rate was significantly decreased in essential hypertensives (P less than 0.001). A significant positive correlation was found between urinary sodium excretion and urinary prostaglandin E excretion in normal subjects (r = 0.39, P less than 0.001), and in essential hypertensives (r = 0.62, P less than 0.001). There was no correlation between the renin-angiotensin-aldosterone system and urinary prostaglandin E excretion in normal subjects as well as in essential hypertensives. The present data show that renal prostaglandin might be involved in the renal handling of sodium, and prove the possibility that the decrease of renal prostaglandin synthesis is one of the etiological factors in essential hypertension.
为研究肾前列腺素在钠代谢调节中的作用，我们测定了84名正常受试者和55名原发性高血压患者在随意摄入钠情况下的尿前列腺素E排泄量（肾前列腺素合成的指标）、尿钠排泄量、血浆肾素活性和尿醛固酮排泄量。正常受试者尿前列腺素E的排泄率为736.8±32.2 ng/天，原发性高血压患者为394.3±28.7 ng/天。原发性高血压患者的排泄率显著降低（P<0.001）。在正常受试者中（r = 0.39，P<0.001）以及原发性高血压患者中（r = 0.62，P<0.001），尿钠排泄量与尿前列腺素E排泄量之间均存在显著正相关。在正常受试者以及原发性高血压患者中，肾素 - 血管紧张素 - 醛固酮系统与尿前列腺素E排泄量之间均无相关性。目前的数据表明，肾前列腺素可能参与了肾脏对钠的处理，并证明了肾前列腺素合成减少是原发性高血压病因之一的可能性。
