Natangelo R, Monarca A, Bastia A, Adelasco L, Croce G
Ann Sclavo. 1980 Nov-Dec;22(6):964-71.
185 asymptomatic heroin addicts in whom the incidence of positivity as for HBsAg was 9.1%, were examined. From the anamnesis, these carriers has a higher frequency of icteric events in comparison with patient controls, while they did not show differences in distribution according to age, duration of the toxicomania and regional origin of the family. 38 heroin addicts were alcoholics too: 6/38 were HBs carriers, whereas 11/147 non alcoholic were carriers. The group of HBsAg positive addicts showed an analogous alteration of the transaminase levels as regards the patient controls, while the incidence of hypoalbuminemia and hypergammaglobulinemia was higher. In consideration of these results, the possible responsibility of toxic factors (alcohol) and alterations of the immune reactivity as to the prolonged permanence of HBsAg in circle is discussed.
对185名无症状海洛因成瘾者进行了检查，其乙肝表面抗原（HBsAg）阳性率为9.1%。从既往史来看，与对照患者相比，这些携带者黄疸事件的发生率更高，而在年龄、毒瘾持续时间和家族地域来源的分布上未显示出差异。38名海洛因成瘾者也是酗酒者：38人中6人是乙肝携带者，而147名非酗酒者中有11人是携带者。HBsAg阳性成瘾者组的转氨酶水平与对照患者相比有类似变化，而低白蛋白血症和高丙种球蛋白血症的发生率更高。考虑到这些结果，讨论了毒性因素（酒精）的可能作用以及免疫反应改变对HBsAg在体内长期持续存在的影响。
