实验性肠系膜闭塞后脂质体在缺血肠中的蓄积

Liposome accumulation in ischaemic intestine following experimental mesenteric occlusion.

作者信息

Palmer T N, Caride V J, Fernandez L A, Twickler J

出版信息

Biosci Rep. 1981 Apr;1(4):337-44. doi: 10.1007/BF01114873.

Abstract

Partial intestinal ischaemia was produced by ligation of selected primary laterals of the mesenteric artery in the rat. Both positively and negatively charged liposomes (multiply labelled with [99mTc]diethylenetriamine pentaacetic acid, [3H]methoxy-inulin, and [4-14C]-cholesterol), administered 24 h following ligation, were accumulated in ischemic (necrotic) intestine.

摘要

通过结扎大鼠肠系膜动脉的特定一级分支来造成部分肠道缺血。在结扎后24小时给予带正电荷和负电荷的脂质体（用[99mTc]二乙三胺五乙酸、[3H]甲氧基菊粉和[4-14C]胆固醇多重标记），它们会在缺血（坏死）肠道中蓄积。