Palmer T N, Warner J P
Biosci Rep. 1983 May;3(5):479-85. doi: 10.1007/BF01121960.
The purpose of this study was to establish whether liposomes administered via the intravenous route promote granulocyte aggregation and pulmonary leukostasis. White cells (labelled with [111In]tropolanate) and positively and negatively charged liposomes (containing entrapped [99mTc]DTPA) were administered i.v. to rats. The blood clearance and tissue distribution of 111In label was not altered by the administration of liposomes (and vice versa) and it is inferred that on intravenous liposome administration liposome/white-cell interactions are unlikely to compromise lung function.
本研究的目的是确定经静脉途径给药的脂质体是否会促进粒细胞聚集和肺白细胞淤滞。将白细胞（用[111In]托泊拉酸盐标记）以及带正电荷和负电荷的脂质体（包封有[99mTc]二乙三胺五乙酸）静脉注射给大鼠。脂质体的给药并未改变111In标记物的血液清除率和组织分布（反之亦然），由此推断，静脉注射脂质体时，脂质体与白细胞的相互作用不太可能损害肺功能。
