Dobbs H J, Barrett A, Rostom A Y, Peckham M J
Br J Radiol. 1981 Oct;54(646):878-81. doi: 10.1259/0007-1285-54-646-878.
Thirty-seven patients with advanced non-Hodgkin's lymphoma who were treated by total-body irradiation (TBI) at the Royal Marsden Hospital are reviewed. Twenty-four patients had received no previous therapy; 13 patients were in relapse. The overall response rate was 73% for nodular lymphomas and 80% for those with diffuse disease. THe duration of complete response ranged from two to 41 months (median 12 months). Subsequent chemotherapy was given successfully except in patients with prolonged thrombocytopenia which appeared to be related to an initially involved bone marrow. Hemibody irradiation (HBI) was the least myelosuppressive form of TBI and is now being used in complete remission following chemotherapy.
对37例在皇家马斯登医院接受全身照射（TBI）治疗的晚期非霍奇金淋巴瘤患者进行了回顾性研究。24例患者此前未接受过治疗；13例患者处于复发状态。结节性淋巴瘤的总体缓解率为73%，弥漫性疾病患者的缓解率为80%。完全缓解的持续时间为2至41个月（中位时间为12个月）。除了血小板减少症持续时间延长的患者（这似乎与最初受累的骨髓有关）外，后续化疗均成功进行。半身照射（HBI）是TBI中骨髓抑制作用最小的形式，目前正用于化疗后的完全缓解期。
