Schwartz J, Reid I A
Endocrinology. 1981 Nov;109(5):1778-80. doi: 10.1210/endo-109-5-1778.
The role of vasopressin in the regulation of blood pressure during nonhypotensive hemorrhage was assessed in conscious dogs. An antagonist of the vasoconstrictor activity of vasopressin was administered (10 microgram/kg) to four normal dogs five min prior to the commencement of a 15 min arterial hemorrhage (1 ml/kg/min). The withdrawn blood was reinfused 15 min after completion of the hemorrhage. In the absence of vasopressin blockade, blood pressure and heart rate did not change significantly, while plasma renin activity increased from 3.8 +/- 0.9 to 10.8 +/- 3.1 ng/ml/3h (P less than 0.005), and plasma corticosteroid concentration increased from 1.5 +/- 0.8 to 8.6 +/- 2.0 microgram/dl (P less than 0.001). Following vasopressin blockade, the same hemorrhage decreased mean arterial pressure from 96 +/- 264 +/- 7 mmHg (P less than 0.001), increased heart rate from 71 +/- 10 to 130 +/- 23 beats/min (P less than 0.05), increased plasma renin activity from 7.1 +/- 0.8 to 30.3 +/- 6.7 ng/ml/3h (P less than 0.005) and increased plasma corticosteroid concentration from 1.9 +/- 0.7 to 11.4 +/- 1.2 microgram/dl (P less than 0.001). These data indicate that vasopressin plays an important role in blood pressure regulation during mild hemorrhage in conscious dogs.
在清醒犬中评估了血管加压素在非低血压性出血期间对血压调节的作用。在15分钟动脉出血（1毫升/千克/分钟）开始前5分钟，给4只正常犬注射血管加压素血管收缩活性拮抗剂（10微克/千克）。出血完成15分钟后将抽出的血液回输。在没有血管加压素阻断的情况下，血压和心率没有明显变化，而血浆肾素活性从3.8±0.9增加到10.8±3.1纳克/毫升/3小时（P<0.005），血浆皮质类固醇浓度从1.5±0.8增加到8.6±2.0微克/分升（P<0.001）。血管加压素阻断后，同样的出血使平均动脉压从96±2降至64±7毫米汞柱（P<0.001），心率从71±10增加到130±23次/分钟（P<0.05），血浆肾素活性从7.1±0.8增加到30.3±6.7纳克/毫升/3小时（P<0.005），血浆皮质类固醇浓度从1.9±0.7增加到11.4±1.2微克/分升（P<0.001）。这些数据表明，血管加压素在清醒犬轻度出血期间的血压调节中起重要作用。
