Charlemagne J
Eur J Immunol. 1981 Sep;11(9):717-21. doi: 10.1002/eji.1830110909.
The effects of X-irradiation were studied on the Mexican axolotl antibody synthesis. To reduce the anti-horse red blood cell (HRBC) antibody titers, 150 rd and smaller doses are ineffective, 200-450 rd are increasingly effective, and 700 rd are maximally effective (and lethal). A significant enhancement of the anti-HRBC titers was observed in low doses (50-150 rd X-irradiated animals). This enhancement was also observed when a low X-ray dose was applied only on the thymic areas. In whole body, but thymus area-shielded, 100 rd X-irradiated animals, the anti-HRBC titers were similar to those of the nonirradiated, HRBC-immunized control group. To explain these phenomena, it is suggested that a radiosensitive, adult thymectomy-sensitive and hydrocortisone-sensitive suppressor T cell subpopulation regulates the antibody synthesis in the axolotl.
研究了X射线照射对墨西哥钝口螈抗体合成的影响。为降低抗马红细胞（HRBC）抗体效价，150拉德及更低剂量无效，200 - 450拉德效果渐强，700拉德效果最佳（且具有致死性）。在低剂量（50 - 150拉德X射线照射的动物）中观察到抗HRBC效价显著增强。当仅对胸腺区域施加低X射线剂量时也观察到这种增强。在全身但胸腺区域屏蔽的情况下，100拉德X射线照射的动物，其抗HRBC效价与未照射、HRBC免疫的对照组相似。为解释这些现象，有人提出一种对辐射敏感、对成年胸腺切除敏感且对氢化可的松敏感的抑制性T细胞亚群调节钝口螈的抗体合成。
