Tournefier A
Immunology. 1982 May;46(1):155-62.
The effect of in vivo hydrocortisone (HC) treatment on thymocytes, splenic and blood lymphocytes and on allogeneic and humoral immune responses were investigated in the axolotl (urodele amphibian). HC induces a profound lymphocytopenia in the thymus (83% HC sensitive) and the spleen (50% HC sensitive) but not in the blood. The density gradient analysis of HC-treated axolotls showed that thymic cell populations of light density were more sensitive than populations of high density. The timing of HC administration in relation to the antigenic challenge is crucial for the humoral immune response. If HC injection is given 8 days before or on the same day as injection of horse red blood cells (HRBC), the antibody response is markedly enhanced. If HC injection occurs 8 days after injection of HRBC or on the day of the maximum anti-HRBC response, the antibody response is unchanged. The allograft immune response is not affected by HC treatment. The parallelism of the enhanced anti-HRBC response after HC treatment, with the same enhanced response obtained in adult thymectomized (ATx) animals, as well as in ATx-HC-treated axolotl, may be explained by the presence of a corticosensitive, T-like population of suppressor cells in axolotl.
研究了体内注射氢化可的松（HC）对美西螈（有尾两栖动物）胸腺细胞、脾淋巴细胞和血液淋巴细胞以及对同种异体免疫和体液免疫反应的影响。HC可导致胸腺（83%的HC敏感性）和脾脏（50%的HC敏感性）出现严重淋巴细胞减少，但对血液中的淋巴细胞无影响。对经HC处理的美西螈进行密度梯度分析表明，低密度胸腺细胞群体比高密度群体更敏感。HC给药时间与抗原刺激的关系对体液免疫反应至关重要。如果在注射马红细胞（HRBC）前8天或同一天注射HC，抗体反应会显著增强。如果在注射HRBC后8天或在抗HRBC反应最强的当天注射HC，抗体反应则无变化。同种异体移植免疫反应不受HC处理的影响。HC处理后抗HRBC反应增强，与成年胸腺切除（ATx）动物以及经ATx - HC处理的美西螈中获得的相同增强反应的平行性，可能是由于美西螈中存在一种对皮质激素敏感的、类似T细胞的抑制细胞群体。
