Peterdy A E, Sutherland J B, Jeffery J, Benediktsson H, Greenberg I D
J Can Assoc Radiol. 1981 Sep;32(3):144-8.
The uptake of technetium-99m sulfur colloid (TSC) by transplanted kidneys undergoing rejection has been described. In this retrospective study, the value of TSC uptake in diagnosing renal rejection was studied in different time intervals after renal transplantation. Within 14 days after transplantation, increasing uptake was seen in 88% of 26 rejection episodes. In patients with acute tubular necrosis, 42% of their studies showed TSC uptake. TSC did not predict rejection within the three days prior to rejection. Sensitivity, specificity and accuracy of 128 TSC studies were compared at different thresholds of TSC uptake; at best, accuracy was only 76%. In later time intervals, a much smaller percentage of patients had increasing uptake with rejection; this tendency was to remain unchanged. Many non-rejection studies showed some TSC uptake. In chronic rejection, persistently marked uptake dominated prior to one year after transplantation, but not beyond this. Thus, within 14 days after transplantation, TSC uptake may support the diagnosis of rejection. Thereafter its value becomes greatly limited.
已有关于发生排斥反应的移植肾对锝-99m硫胶体（TSC）摄取情况的描述。在这项回顾性研究中，对肾移植术后不同时间间隔内TSC摄取在诊断肾排斥反应中的价值进行了研究。移植后14天内，26次排斥反应中有88%出现摄取增加。在急性肾小管坏死患者中，其检查中有42%显示TSC摄取。TSC无法在排斥反应前三天内预测排斥反应。在TSC摄取的不同阈值下，对128项TSC检查的敏感性、特异性和准确性进行了比较；最高准确率仅为76%。在之后的时间间隔内，因排斥反应而摄取增加的患者比例要小得多；这种趋势保持不变。许多非排斥反应检查也显示出一定的TSC摄取。在慢性排斥反应中，移植后一年内持续出现明显摄取，但超过一年后则不然。因此，移植后14天内，TSC摄取可能有助于排斥反应的诊断。此后其价值就会大大受限。
