Peachey J E, Brien J F, Roach C A, Loomis C W
J Clin Psychopharmacol. 1981 Jan;1(1):21-6. doi: 10.1097/00004714-198101000-00005.
Disulfiram and calcium carbimide are widely used alcohol deterrents. Their safe use, however, requires a knowledge of their pharmacology, toxicity, and interactions with alcohol and other drugs. The absorption, metabolism, and elimination of these compounds are described, and elimination of these compounds are described, as is the mechanism of their reaction with ethanol. The effects and limitations of the interaction between ethanol and disulfiram and calcium carbimide are discussed. Four areas of concern regarding toxicity are discussed, including medical complications of the reactions with alcohol, toxicity associated with repeated doses of disulfiram or calcium carbimide, possible interactions with other drugs, and acetaldehyde-induce hepatotoxicity and cardiotoxicity.
双硫仑和卡马西平是广泛使用的戒酒药。然而，它们的安全使用需要了解其药理学、毒性以及与酒精和其他药物的相互作用。文中描述了这些化合物的吸收、代谢和消除情况，以及它们与乙醇反应的机制。还讨论了乙醇与双硫仑和卡马西平相互作用的效果和局限性。文中讨论了四个关于毒性的关注点，包括与酒精反应的医学并发症、重复使用双硫仑或卡马西平相关的毒性、与其他药物可能的相互作用，以及乙醛诱导的肝毒性和心脏毒性。
