双相情感障碍锂盐治疗的历史回顾与当前要点

Historical perspectives and current highlights on lithium treatment in manic-depressive illness.

作者信息

Georgotas A, Gershon S

出版信息

J Clin Psychopharmacol. 1981 Jan;1(1):27-31. doi: 10.1097/00004714-198101000-00006.

DOI:10.1097/00004714-198101000-00006

Abstract

This article reviews the use of lithium from Roman times, when physicians first recommended alkaline springs in the treatment of mania, to the present. Serious interest in lithium began in 1949, with a report of improvement of mania in 10 of 10 patients. Since then, lithium has become increasingly popular both for treating acute mania and as a prophylactic agent. Its use in depression is also described. Finally, lithium's clinical spectrum is discussed, noting that its use extends far beyond the treatment of mania.

摘要

本文回顾了锂的使用历程，从罗马时代医生首次推荐碱性泉水治疗躁狂症开始，直至现代。对锂的浓厚兴趣始于1949年，当时有报告称10名患者中有10名躁狂症状得到改善。从那时起，锂在治疗急性躁狂症以及作为预防药物方面越来越受欢迎。文中还描述了其在抑郁症治疗中的应用。最后，讨论了锂的临床应用范围，指出其用途远远超出了躁狂症的治疗。