Khan J A, Marcus P, Cummings S W
J Laryngol Otol. 1981 Oct;95(10):995-1001. doi: 10.1017/s002221510009174x.
S-carboxymethylcysteine syrup (SCMC); brompheniramine, phenylephrine with phenylpropanolamine elixir (BPP); and a placebo were compared in a double-blind trial in 58 children with otitis media with effusion (OME). All patients underwent myringotomies after an initial period of medical treatment. SCMC, but not BPP, was significantly better than the placebo in speeding up resolution of the effusion after surgery, as judged by pure tone audiometry, showing this drug to be a useful adjunct to the surgical management of OME. It should also be considered as an alternative to surgery.
在一项针对58名中耳积液（OME）患儿的双盲试验中，对S-羧甲基半胱氨酸糖浆（SCMC）、含溴苯那敏、去氧肾上腺素和苯丙醇胺的酏剂（BPP）以及安慰剂进行了比较。所有患者在初始药物治疗一段时间后均接受了鼓膜切开术。通过纯音听力测定法判断，SCMC而非BPP在加速术后积液消退方面显著优于安慰剂，表明该药物是OME手术治疗的有用辅助药物。它也应被视为手术的替代方案。
