Madoule P, Trampont P, Doyon D, Quillard J, Puisieux F
J Radiol. 1981 Aug-Sep;62(8-9):457-62.
A study was conducted in dogs to evaluate the effect on the organism of a new embolisation material: carnauba wax micropellets. The ultimate objective was to study the possible use of micropellets containing an active product for therapy in situ. Renal embolisation was performed by selective or highly selective arterial catheterisation in dogs. Pathological examination demonstrated that only mild foreign body reactions occurred at the embolisation site. Overall tolerance was good. The micropellets were shown to possess some biodegradation properties and to be susceptible to deformation. An attempt is made to define the ideal micropellet from the point of view of size, kinetic features, and biodegradation properties.
在犬类动物中开展了一项研究，以评估一种新型栓塞材料——巴西棕榈蜡微球对机体的影响。最终目的是研究含有活性产品的微球用于原位治疗的可能性。通过对犬类进行选择性或高选择性动脉插管来实施肾栓塞。病理检查表明，栓塞部位仅出现轻度异物反应。总体耐受性良好。已证明微球具有一些生物降解特性且易于变形。人们尝试从尺寸、动力学特征和生物降解特性的角度来定义理想的微球。
