Bernstein I D, Wright P W
Natl Cancer Inst Monogr. 1981 Apr(56):177-82.
Tumor antigens have now been demonstrated for most experimentally induced tumors by in vivo transplantation techniques, but the demonstration of antigens unique to human tumors has depended on in vitro methods. We have reviewed 1) the evidence that experimental sarcomas express tumor-specific transplantation antigens and that responses against these antigens can be protective in vivo; 2) the in vitro evidence for the existence to antigens associated with sarcomas; and 3) the use of cell hybridization techniques to produce monoclonal antibody to define the distribution of cell surface antigens expressed by human sarcoma cells.
目前，通过体内移植技术已在大多数实验诱导的肿瘤中证实了肿瘤抗原，但人类肿瘤特有的抗原的证实则依赖于体外方法。我们回顾了：1）实验性肉瘤表达肿瘤特异性移植抗原且针对这些抗原的反应在体内具有保护作用的证据；2）肉瘤相关抗原存在的体外证据；3）利用细胞杂交技术制备单克隆抗体以确定人类肉瘤细胞表达的细胞表面抗原的分布情况。
