Rosenberg S A, Parker G A, Thorpe W P
Isr J Med Sci. 1978 Jan;14(1):98-104.
Normal mouse tissues in tissue culture express fetal antigens that are not expressed on these same tissues in vivo. The fetal antigens expressed on normal mouse cells in vitro are also expressed on at least two murine sarcomas, and account for the cross-reactive antibodies between these tumors. The fetal antigens are distinct from unique tumor-specific antigens found on these neoplasms. Normal human cells in tissue culture also express antigens found in human fetuses during the first trimester of pregnancy. Many human sera contain natural antibodies directed against the fetal antigens appearing in vitro. The expression of oncofetal antigens by normal cells in tissue culture must be taken into account in the interpretation of results of studies in tumor immunology in which tissue-cultured cells are utilized.
组织培养中的正常小鼠组织表达在体内相同组织上不表达的胎儿抗原。体外正常小鼠细胞上表达的胎儿抗原在至少两种鼠肉瘤上也有表达，并解释了这些肿瘤之间的交叉反应性抗体。胎儿抗原与这些肿瘤上发现的独特肿瘤特异性抗原不同。组织培养中的正常人类细胞也表达妊娠头三个月人类胎儿中发现的抗原。许多人血清含有针对体外出现的胎儿抗原的天然抗体。在利用组织培养细胞的肿瘤免疫学研究结果解释中，必须考虑组织培养中正常细胞癌胚抗原的表达。
