Dournon E, Le Bras J, Charmot G, Frottier J, Bastin R
Nouv Presse Med. 1981 Oct 31;10(39):3233-6.
In a patients with P. falciparum malaria contracted in Thailand, the course of the disease under treatment suggested resistance to both chloroquine and pyrimethamine-sulfadoxine, as well as reduced sensitivity to quinine. This was confirmed by in vitro tests on continuous culture of the strain. Therapeutic success was obtained with a quinine-cycline combination. The problems raised by the emergence of P. Falciparum strains resistant to polychemotherapy are emphasized.
在一名于泰国感染恶性疟原虫疟疾的患者中，治疗过程显示对氯喹和乙胺嘧啶 - 磺胺多辛均有耐药性，对奎宁的敏感性也降低。对该菌株连续培养的体外试验证实了这一点。使用奎宁 - 四环素联合治疗取得了治疗成功。强调了耐多药恶性疟原虫菌株出现所引发的问题。
