Hayashi M, Saruta T, Nakamura R, Kitajima W, Kato E
Ren Physiol. 1981;4(1):17-21. doi: 10.1159/000172799.
To investigate the relation between renin content in each juxtaglomerular apparatus and reduction of plasma renin activity (PRA) with aging, the PRA and microdissected superficial or juxtamedullary single nephron renin content (SNRC) were determined in 5 young (3-6 months) and 5 aged (13-18 months) rats fed on a normal salt diet. The mean value of the PRA in the aged group was significantly lower than that of the young group. A highly significant correlation was found between the RPA and mean values of the superficial SNRC. The mean values of both the superficial and deep SNRC in the aged rats were significantly lower than those of the corresponding zones in the young rats. It is suggested that decreased synthesis of renin in each juxtaglomerular apparatus is an important factor in the decreased PRA observed with aging.
为研究各肾小球旁器中肾素含量与衰老过程中血浆肾素活性（PRA）降低之间的关系，对5只正常盐饮食的年轻（3 - 6个月）大鼠和5只老年（13 - 18个月）大鼠测定了PRA以及经显微解剖的浅表或近髓单肾单位肾素含量（SNRC）。老年组的PRA平均值显著低于年轻组。发现RPA与浅表SNRC平均值之间存在高度显著的相关性。老年大鼠浅表和深部SNRC的平均值均显著低于年轻大鼠相应区域的平均值。提示各肾小球旁器中肾素合成减少是衰老过程中观察到的PRA降低的一个重要因素。
