Wilson M F, Brackett D J, Hinshaw L B, Tompkins P, Archer L T, Benjamin B A
Surg Gynecol Obstet. 1981 Dec;153(6):869-72.
Plasma vasopressin concentration was measured by radioimmunoassay in lightly anesthetized baboons and dogs before and during experimental Escherichia coli septic shock. Since vasopressin is a potent vasoconstrictor, and activator of clotting factors and a myocardial depressant, we postulated that, if found in substantial amounts in the plasma, vasopressin may contribute to the physiopathology of the septic shock syndrome. Quite high plasma vasopressin concentrations were found in both baboons and dogs. In the baboons, increased plasma vasopressin concentrations occurred, while mean arterial blood pressure was still within normal limits and remained elevated for as long as 12 hours during septic shock. Plasma vasopressin concentrations of this magnitude have been previously reported only with direct hypothalamic stimulation or after hypotensive shock secondary to hemorrhage.
在轻度麻醉的狒狒和狗身上，于实验性大肠杆菌败血症休克之前及期间，通过放射免疫分析法测量血浆血管加压素浓度。由于血管加压素是一种强效血管收缩剂、凝血因子激活剂及心肌抑制剂，我们推测，如果在血浆中发现大量血管加压素，它可能会促成败血症休克综合征的病理生理过程。在狒狒和狗身上均发现血浆血管加压素浓度相当高。在狒狒身上，血浆血管加压素浓度升高，而平均动脉血压仍在正常范围内，并且在败血症休克期间长达12小时一直保持升高。此前仅在直接下丘脑刺激后或继发于出血的低血压休克后才报道过如此高的血浆血管加压素浓度。
