Lindros K O, Stowell A, Pikkarainen P, Salaspuro M
Alcohol Clin Exp Res. 1981 Fall;5(4):528-30. doi: 10.1111/j.1530-0277.1981.tb05354.x.
4-methylpyrazole (4-MP), an inhibitor of alcohol dehydrogenase, rapidly abolished the accumulation of acetaldehyde following alcohol ingestion both in volunteers pretreated with the Antabuse analog calcium carbimide and in an antabuse-treated alcoholic. 4-MP also attenuated other typical symptoms, including facial flushing and tachycardia, thus suggesting its usefulness in the acute treatment of severe disulfiram-alcohol reactions.
4-甲基吡唑（4-MP）是一种酒精脱氢酶抑制剂，在服用戒酒硫类似物卡巴咪嗪预处理的志愿者以及接受戒酒硫治疗的酗酒者中，它能迅速消除饮酒后乙醛的蓄积。4-MP还能减轻其他典型症状，包括面部潮红和心动过速，因此表明其在严重双硫仑-酒精反应的急性治疗中有用。
