Guilhou J J, Malbos S, Delalleau D, Meynadier J
Arch Dermatol Res. 1981;271(3):295-303. doi: 10.1007/BF00409458.
Sixteen psoriatic patients and 11 control subjects were investigated by immunofluorescence for skin immunoglobulins (IG) and complement (c) deposits and for keratinocyte membrane markers with anti beta 2 microglobulin (beta 2 m) antibodies (Ab), Con A, and pemphigus Ab. IG and/or c deposits were almost constant in involved epidermis. Three patterns were associated: (1) parakeratotic nuclear (dots-dashes), (2) stratum corneum (SC) intercellular (lamellar pattern), (3) vascular (granular or linear deposits in papillary dermal vessels). In uninvolved epidermis nuclear or vascular deposits could occasionally be present but intercellular pattern was never found in SC. Control specimens were always negative. The three surface markers investigated (beta 2 m, Con A receptor, Pemphigus antigen) could be demonstrated on psoriatic keratinocytes with only slight differences in distribution when compared with controls. Thus, by this methodology no important abnormality could be found in psoriatic keratinocyte membrane antigens.
对16例银屑病患者和11例对照受试者进行免疫荧光检查，以检测皮肤免疫球蛋白（IG）和补体（c）沉积，以及用抗β2微球蛋白（β2m）抗体（Ab）、刀豆球蛋白A（Con A）和天疱疮抗体检测角质形成细胞膜标志物。IG和/或c沉积在受累表皮中几乎恒定。有三种相关模式：（1）角化不全细胞核（点-线），（2）角质层（SC）细胞间（层状模式），（3）血管（乳头真皮血管中的颗粒状或线状沉积）。在未受累表皮中，偶尔可见细胞核或血管沉积，但在SC中从未发现细胞间模式。对照标本始终为阴性。与对照相比，所研究的三种表面标志物（β2m、Con A受体、天疱疮抗原）在银屑病角质形成细胞上均可显示，仅分布略有差异。因此，通过这种方法，在银屑病角质形成细胞膜抗原中未发现重要异常。
