Hansen S R
Arch Environ Contam Toxicol. 1981 Sep;10(5):597-603. doi: 10.1007/BF01054882.
The use of empirical and mechanistic approaches are possible in the development of tests to screen for a substance's potential to affect interspecies interactions. The advantages and disadvantages of the two approaches are discussed. An experimental study is presented, in which an empirical and a mechanistic screening test for effects on exploitative competition between bacterial species were established and perturbed with nalidixic acid. Comparison of test results indicates that the mechanistic test was faster, cheaper, more sensitive, and more quantitative. The empirical test attained similar sensitivity and quantification only if the dynamics of the competition event was continuously monitored; requiring even greater cost and time.
在开发用于筛选物质影响种间相互作用潜力的测试方法时，经验性方法和机理方法都是可行的。本文讨论了这两种方法的优缺点。文中介绍了一项实验研究，其中建立了针对细菌物种间剥削性竞争影响的经验性和机理性筛选测试，并使用萘啶酸进行干扰。测试结果比较表明，机理性测试更快、更便宜、更灵敏且更具定量性。只有在持续监测竞争事件动态的情况下，经验性测试才能达到类似的灵敏度和定量性，这需要更高的成本和时间。
