Zarate A, Canales E S, Sthory I, Coy D H, Comaru-Schally A M, Schally A V
Contraception. 1981 Sep;24(3):315-20. doi: 10.1016/0010-7824(81)90044-5.
The antagonistic analog of LHRH, NAc-D-p-Cl-Phe(1),(2), D-Trp(3),D-Phe(6), D-Ala(10)-LHRH was administered intramuscularly in a dose of 2 mg to ten normally ovulating women on day 12 of the menstrual cycle. Ovulation was inhibited in six patients, and two more presented an insufficient corpus luteum. No pregnancies were recorded in this series. In those patients who did not ovulate, it was demonstrated that the LHRH analog abolished the midcycle surge of both LH and FSH. Luteolysis evidenced by the rapid decline in progesterone levels was present in 2 cases. Bleeding pattern showed a tendency to delayed menses. The morphological findings in endometrial biopsies of 6 women exhibited mild proliferation. Further research along these lines is necessary for appraisal of this approach to birth control.
在月经周期的第12天，对10名正常排卵的女性肌肉注射2毫克促黄体生成素释放激素（LHRH）的拮抗类似物NAc-D-p-对氯苯丙氨酸（1），（2），D-色氨酸（3），D-苯丙氨酸（6），D-丙氨酸（10）-LHRH。6名患者的排卵受到抑制，另外两名患者黄体功能不足。该组未记录到怀孕情况。在那些未排卵的患者中，证明LHRH类似物消除了促黄体生成素（LH）和促卵泡生成素（FSH）的周期中期高峰。2例出现孕酮水平迅速下降所证明的黄体溶解。出血模式显示有月经延迟的倾向。6名女性子宫内膜活检的形态学结果显示有轻度增生。为评估这种避孕方法，有必要沿着这些方向进行进一步研究。
