Firrao S
G Batteriol Virol Immunol. 1980 Jul-Dec;73(7-12):202-8.
Application of the probability calculus to the variational structure of the immunoglobulins leads to demonstrate the impossibility of the random production of the repertory's antibodies. Physical and Cybernetic considerations lead, instead, to demonstrate the necessary existence of aspecific recognition of the antigen, i.e. of the antigen's activity. Application of the theory of stochastic convergence, at last, leads to demonstrate that, if there would be a connection between this aspecific recognition and the antibody's production, the latter would be possible. This connection, as a consequence, must exist.
将概率计算应用于免疫球蛋白的变构结构,可证明抗体库中抗体随机产生是不可能的。相反,基于物理学和控制论的思考可证明对抗原(即抗原活性)进行非特异性识别的必然存在。最后,应用随机收敛理论可证明,如果这种非特异性识别与抗体产生之间存在联系,那么抗体产生就是可能的。因此,这种联系必然存在。