Sclafani A, Xenakis S
J Comp Physiol Psychol. 1981 Oct;95(5):708-19. doi: 10.1037/h0077829.
Adult female rats given bilateral parasagittal knife cuts in the medial hypothalamus (VMH group) were hyperphagic and became obese on a chow diet, compared with sham-operated controls. The VMH rats also overconsumed, relative to controls, sucrose and glucose solutions during 30 min/day tests. Pretreating the VMH and control rats with atropine methyl nitrate (1.0, 5.0, or 10.0 mg/kg) reduced their intake of the sugar solutions in three out of five experiments, and in all experiments it suppressed their 24-hr chow intake. However, the VMH rats continued to drink more of the sugar solutions than did the controls after all atropine treatments, and in three out of four experiments their hyperphagia on the chow diet was not blocked by the atropine. The results do not support the hypothesis that vagally stimulated insulin release or other cholinergically mediated cephalic responses of digestion are essential for the expression of hypothalamic hyperphagia and finickiness.
与假手术对照组相比，在内侧下丘脑进行双侧矢状旁切口的成年雌性大鼠（VMH组）食量过大，以普通饲料喂养时会变得肥胖。在每天30分钟的测试中，VMH大鼠相对于对照组也过量摄入蔗糖和葡萄糖溶液。用硝酸甲基阿托品（1.0、5.0或10.0mg/kg）预处理VMH大鼠和对照大鼠，在五个实验中有三个实验减少了它们对糖溶液的摄入量，并且在所有实验中都抑制了它们24小时的普通饲料摄入量。然而，在所有阿托品处理后，VMH大鼠继续比对照大鼠饮用更多的糖溶液，并且在四个实验中有三个实验中，它们对普通饲料的食欲亢进并未被阿托品阻断。这些结果不支持以下假设，即迷走神经刺激的胰岛素释放或其他胆碱能介导的消化性头期反应对于下丘脑性食欲亢进和挑食的表达至关重要。
