Liljenquist J E, Lewis S B, Cherrington A D, Sinclair-Smith B C, Lacy W W
Metabolism. 1981 Dec;30(12):1195-9. doi: 10.1016/0026-0495(81)90041-x.
Four normal and five insulin dependent diabetic men received a 2 h pharmacologic glucagon infusion (50 ng/kg/min) resulting in plasma glucagon levels (4400 pg/ml) similar to those seen in glucagonoma patients. In normal subjects in whom plasma insulin concentrations rose significantly (239 uU/ml) and the blood level of 15 of the 18 amino acids measured fell significantly. In contrast, in the diabetic men who secreted no insulin in response to glucagon (no rise in C-peptide levels), only 10 of 18 amino acid levels fell significantly. The branched chain amino acids valine, leucine and isoleucine, as well as tyrosine and phenylalanine were among the 8 amino acids which showed no change in response to glucagon in the diabetics. Thus, glucagon appears to have no acute affect on branched chain amino acid levels in man.
四名正常男性和五名胰岛素依赖型糖尿病男性接受了两小时的胰高血糖素药物输注（50纳克/千克/分钟），使得血浆胰高血糖素水平（4400皮克/毫升）与胰高血糖素瘤患者的水平相似。在正常受试者中，血浆胰岛素浓度显著升高（239微单位/毫升），所检测的18种氨基酸中的15种血液水平显著下降。相比之下，在对胰高血糖素无胰岛素分泌反应（C肽水平无升高）的糖尿病男性中，18种氨基酸水平中只有10种显著下降。支链氨基酸缬氨酸、亮氨酸和异亮氨酸，以及酪氨酸和苯丙氨酸是糖尿病患者中对胰高血糖素无反应变化的8种氨基酸之一。因此，胰高血糖素似乎对人体支链氨基酸水平没有急性影响。
