Doffoël M, Vetter D, Schlienger J L, Sapin R, Doffoël S, Bockel R
Presse Med. 1984 Oct 6;13(35):2129-32.
In order to investigate disturbances in glycoregulation and plasma amino acids and their possible relationship in alcoholic liver diseases, plasma concentrations of insulin, C-peptide, glucagon and branched-chain (valine, leucine, isoleucine) as well as aromatic (phenylalanine, tyrosine) amino acids were measured during an arginine test (i.v infusion of arginine chloride 0.5 g/kg over 30 min) in 21 alcoholic patients: 11 with cirrhosis (group C) and 10 with steatosis (group S). Insulin responses to arginine was reduced in both groups, whereas glucagon response was increased in group C and reduced in group S. Plasma concentrations of branched-chain amino acids were reduced in both groups, irrespective of the degree of hyperinsulinism. Plasma concentrations of aromatic amino acids were increased only in cirrhotic patients; the increase was independent of the degree of hyperglucagonism and of the plasma insulin/glucagon molar ratio. These results suggest that disturbances of glycoregulation in plasma amino acids imbalance do not play a major role in alcoholic cirrhosis and steatosis.
为了研究酒精性肝病患者糖调节及血浆氨基酸紊乱情况及其可能的关系，对21例酒精性肝病患者进行精氨酸试验（30分钟内静脉输注0.5g/kg氯化精氨酸），测定血浆胰岛素、C肽、胰高血糖素、支链氨基酸（缬氨酸、亮氨酸、异亮氨酸）以及芳香族氨基酸（苯丙氨酸、酪氨酸）的浓度，其中11例为肝硬化患者（C组），10例为脂肪变性患者（S组）。两组患者对精氨酸的胰岛素反应均降低，而C组患者的胰高血糖素反应增强，S组患者的胰高血糖素反应降低。两组患者的支链氨基酸血浆浓度均降低，与高胰岛素血症程度无关。仅肝硬化患者的芳香族氨基酸血浆浓度升高，该升高与高胰高血糖素血症程度及血浆胰岛素/胰高血糖素摩尔比无关。这些结果表明，血浆氨基酸失衡所致的糖调节紊乱在酒精性肝硬化和脂肪变性中不起主要作用。
