Frentz G D, Schlegel J U, Hussey J L, Prima R
Urology. 1981 Dec;18(6):546-55. doi: 10.1016/0090-4295(81)90454-4.
Renal transplant recipients and donors were studied serially with quantitative renal scintillation camera studies utilizing 131I-Hippuran and 99mTc-Iron ascorbate. This study allows for determination of effective renal plasma flow (ERPF), glomerular filtration rate (GFR), filtration fraction (FF), and predicted return in ten minutes. A drop in FF occurred with, or preceded clinical rejection; whereas, an increase in FF occurred with acute tubular necorsis (ATN) caused by preservation injury, aminoglycosides, and following acute rejection. Combined with the other parameters of renal function determined by this technique, FF alterations proved useful in the differentiation of ATN from rejection and in predicting the prognosis of renal homografts.
采用¹³¹I-马尿酸钠和⁹⁹ᵐTc-抗坏血酸铁，通过定量肾闪烁照相机研究对肾移植受者和供者进行了连续观察。本研究可测定有效肾血浆流量（ERPF）、肾小球滤过率（GFR）、滤过分数（FF）以及预测的十分钟内恢复情况。滤过分数下降发生在临床排斥反应时或之前；而滤过分数升高则发生在由保存损伤、氨基糖苷类药物引起的急性肾小管坏死（ATN）时以及急性排斥反应之后。结合通过该技术测定的其他肾功能参数，滤过分数的改变被证明有助于区分急性肾小管坏死与排斥反应，并预测同种肾移植的预后。
