Mirani-Oostdijk C P, van Gent C M, Terpstra J, Hessel L W, Frölich M
Acta Med Scand. 1981;210(4):277-82. doi: 10.1111/j.0954-6820.1981.tb09815.x.
Diurnal levels of serum triglyceride (TG), cholesterol, free fatty acids (FFA), glucose and insulin were measured in three type IV hyperlipidemic patients on a fixed solid 65% carbohydrate and a 65% fat diet when in steady state conditions in a metabolic unit. The carbohydrate-rich food was divided into either three or eight equivalent portions, differently spaced over the day and night. The fat-rich food was given in three equivalent portions only. The diurnal TG profiles on these diets showed the same characteristics as those found in normals, but increments and mean levels were considerably higher. On the carbohydrate-rich diet, mean TG levels decreased during the study. This was not seen either on the fat-rich diet or in normals. In contrast to our findings in normals, chylomicrons formed the major contribution to the serum TG pattern. FFA levels were markedly higher on the high-fat than on the carbohydrate-rich diet, but not different from those in normals. Postprandial glucose responses did not differ significantly between the diets. Insulin responses were markedly higher on the carbohydrate-rich than on the fat-rich food. Glucose levels did not differ from those in normals. Insulin levels were significantly higher in the patients. Cholesterol showed minimal fluctuations, parallel to the TG pattern, which could be attributed to chylomicron cholesterol.
在代谢病房的稳定状态下，对三名IV型高脂血症患者进行了研究，分别给予固定的固体饮食，其中碳水化合物含量为65%和脂肪含量为65%，同时测量其血清甘油三酯（TG）、胆固醇、游离脂肪酸（FFA）、葡萄糖和胰岛素的昼夜水平。富含碳水化合物的食物分为三等份或八等份，在白天和晚上不同时间间隔给予。富含脂肪的食物仅分为三等份给予。这些饮食的昼夜TG谱显示出与正常人相同的特征，但升高幅度和平均水平明显更高。在富含碳水化合物的饮食中，研究期间平均TG水平下降。在富含脂肪的饮食中或正常人中均未观察到这种情况。与我们在正常人中的发现相反，乳糜微粒是血清TG模式的主要组成部分。高脂肪饮食时FFA水平明显高于富含碳水化合物的饮食，但与正常人无差异。不同饮食之间餐后血糖反应无显著差异。富含碳水化合物的食物的胰岛素反应明显高于富含脂肪的食物。葡萄糖水平与正常人无差异。患者的胰岛素水平明显更高。胆固醇波动最小，与TG模式平行，这可能归因于乳糜微粒胆固醇。
