Woodward J R, Kornberg H L
Biochem J. 1981 May 15;196(2):531-6. doi: 10.1042/bj1960531.
The general amino acid permease ('Gap') system of the wild-type yeast (Saccharomyces cerevisiae) strain Y185 is inhibited by the uptake and accumulation of its substrate amino acids. Surprisingly, this inhibition persists even after 'pools' of amino acids, accumulated initially, have returned to normal sizes. Recovery from this inhibition depends on a supply of energy and involves the synthesis of a membrane protein component of the Gap system.
野生型酵母(酿酒酵母)菌株Y185的一般氨基酸通透酶(“Gap”)系统会受到其底物氨基酸的摄取和积累的抑制。令人惊讶的是,即使最初积累的氨基酸“池”已恢复到正常大小,这种抑制作用仍然持续。从这种抑制中恢复取决于能量供应,并涉及Gap系统膜蛋白成分的合成。