Hunting D, Hordern J, Henderson J F
Can J Biochem. 1981 Oct;59(10):821-9. doi: 10.1139/o81-114.
The effect of changes in ribonucleoside triphosphate concentrations on those of deoxyribonucleotides has been determined in Chinese hamster ovary K-1 cells. Ribonucleoside triphosphate concentrations were manipulated by the use of drugs or naturally occurring purines or pyrimidines. Changes in the concentration of each ribonucleoside triphosphate led to changes in the concentration of each corresponding deoxyribonucleoside triphosphate. The relationships between the concentrations of CTP and dCTP and between those of GTP and dGTP were linear over a wide range. The relationship between the concentrations of ATP and dATP was linear over the narrow range studied, while the relationship between UTP and dTTP concentrations was curvilinear. Overall, these results demonstrate that ribonucleotides play an important role in controlling deoxyribonucleotide concentrations but the exact mechanism of this control remains to be determined.
已在中国仓鼠卵巢K - 1细胞中测定了三磷酸核糖核苷浓度变化对脱氧核糖核苷酸浓度的影响。通过使用药物或天然存在的嘌呤或嘧啶来控制三磷酸核糖核苷的浓度。每种三磷酸核糖核苷浓度的变化都会导致相应的每种脱氧三磷酸核糖核苷浓度的变化。在很宽的范围内，CTP和dCTP浓度之间以及GTP和dGTP浓度之间的关系呈线性。在所研究的较窄范围内，ATP和dATP浓度之间的关系呈线性，而UTP和dTTP浓度之间的关系呈曲线。总体而言，这些结果表明核糖核苷酸在控制脱氧核糖核苷酸浓度方面起着重要作用，但这种控制的确切机制仍有待确定。
