血液透析治疗期间卡托普利（SQ 14225）的清除率。
Captopril (SQ 14225) clearance during hemodialysis treatment.
作者信息
Hirakata H, Onoyama K, Iseki K, Omae T, Fujimi S, Kawahara Y
出版信息
Clin Nephrol. 1981 Dec;16(6):321-3.
PMID:7032776
Abstract
The clearance of Captopril (SQ 14225) was examined in six hemodialysis patients, using a newly developed method for the determination of Captopril in blood. At 30 minutes after the start of hemodialysis, the clearance of Captopril was 80 +/- 14.2 ml/min, whereas that of creatinine was 123.4 +/- 8.8 ml/min and that of BUN was 144.1 +/- 7.2 ml/min. The blood concentration of Captopril was found to be lower when taken in a postprandial state than in a fasting state.
摘要
使用一种新开发的血液中卡托普利测定方法，对6名血液透析患者的卡托普利（SQ 14225）清除率进行了检测。血液透析开始30分钟后，卡托普利的清除率为80±14.2毫升/分钟，而肌酐的清除率为123.4±8.8毫升/分钟，尿素氮的清除率为144.1±7.2毫升/分钟。发现卡托普利在餐后状态下摄入时的血药浓度低于空腹状态。
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