雄激素敏感性与自身免疫性疾病。I. 性别和睾酮对自身免疫性和非自身免疫性小鼠品系对绵羊红细胞体液免疫反应的影响。
Androgen sensitivity and autoimmune disease. I. Influence of sex and testosterone on the humoral immune response of autoimmune and non-autoimmune mouse strains to sheep erythrocytes.
作者信息
Morton J I, Weyant D A, Siegel B V, Golding B
出版信息
Immunology. 1981 Dec;44(4):661-9.
Abstract
Pre- and post-puberal NZB, DBA/2 and BALB/c mice showed no sex differences in primary IgM plaque-forming cell responses to sheep erythrocyte immunization. Orchiectomy increased and testosterone implants reduced antibody responses only if followed by sublethal irradiation suggesting that androgens may affect rapidly regenerating stem cells and/or their differentiating progeny. Strain differences in target organ sensitivity to androgen were not observed suggesting that NZB autoimmunity does not arise from a pathologic defect in androgen responsiveness.
摘要
青春期前和青春期后的新西兰黑鼠（NZB）、DBA/2 小鼠和 BALB/c 小鼠在对绵羊红细胞免疫的原发性 IgM 斑块形成细胞反应中未表现出性别差异。仅在接受亚致死剂量照射后，去势会增强抗体反应，而睾酮植入则会降低抗体反应，这表明雄激素可能影响快速再生的干细胞和/或其分化后代。未观察到靶器官对雄激素敏感性的品系差异，这表明 NZB 自身免疫并非源于雄激素反应性的病理缺陷。
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